PAUL JAY MARKOVITZ, M.D., PH.D.

-Curriculum Vitae-

 

OFFICE ADDRESS: 2101 Richmond Road

La Place Suite 1030

Beachwood, Ohio 44122-1390

 

Telephone: (216) 591-0006

Fax: (216) 591-0104

EDUCATION:

8/82 - 5/85 M.D.

5/77 - 6/78 Case Western Reserve University

Cleveland, Ohio 44106

7/78 - 6/82 Ph.D. Biochemistry

Case Western Reserve University

Cleveland, Ohio 44106

8/73 - 5/77 B.A. Chemistry   

Case Western Reserve University

Cleveland, Ohio 44106

PROFESSIONAL TRAINING:  

7/87 - 6/89 Residency Program in Psychiatry

The Cleveland Clinic Foundation

9500 Euclid Avenue

Cleveland, Ohio 44106

6/86 - 6/87 Postdoctoral Fellow in Neuropharmacology

MRC Department of Clinical Pharmacology

Oxford University

Radcliffe Infirmary

Oxford, U.K. OX2 6HE

7/85 - 6/86 Residency Program in Psychiatry

University Hospitals of Cleveland

2074 Abington Road

Cleveland, Ohio 44106

9/84 - 7/85 Postdoctoral Fellow in Human Genetics

Veterans' Administration and Dept. of Medicine

Case Western Reserve University

Cleveland, Ohio 44106

PROFESSIONAL APPOINTMENTS:

7/93 - present Assistant Clinical Professor of Psychiatry Case Western Reserve University School of Medicine

Cleveland, Ohio 44106

7/93 - present Director, Mood and Anxiety Research Center, Inc.

Director, Psychiatric Development Research, Inc.

2101 Richmond Road Suite 1030

Beachwood, Ohio 44122-1390

10/93 - 12/94 Medical Director, Progressive Clinical Services of Cleveland

90251 Rockside Road

Valley View, Ohio 44125

7/90 - 6/93 Assistant Professor of Psychiatry

Case Western Reserve University

School of Medicine

Director, Personality Disorders Program

University Hospitals of Cleveland

11400 Euclid Avenue Suite 200

Cleveland, Ohio 44106

10/89 - 6/90 Clinical Instructor

Department of Psychiatry

University Hospitals of Cleveland

2074 Abington Road

Cleveland, Ohio 44106

HONORS & AWARDS:

4/90 First Place - Ohio Psychiatric Association Award in

recognition of outstanding research during 1989

6/89 Richard M. Steinhilber Award in recognition of the pursuit of

knowledge and research excellence in the 1989 academic year

6/89 First Place Research Award in Basic Sciences at the Cleveland Clinic Foundation's Annual Psychiatry and Psychology Research Day

6/86 - 6/87 NATO Postdoctoral Fellowship in Science awarded through

the National Science Foundation for study abroad

8/77 - 5/85 Medical Scientist Training Program

Case Western Reserve University

5/77 Graduated cum laude

Case Western Reserve University

8/73 - 5/74 Presidential Scholarship

Case Western Reserve University

OHIO MEDICAL LICENSE: 35-05-4221

AFFILIATIONS: American Psychiatric Association

Ohio Psychiatric Association

Cleveland Psychiatric Association

Society of Biological Psychiatry

International Society for the Study of Personality

Society of Biological Psychiatry

REFEREE - JOURNALS: Journal of Clinical Psychopharmacology

Journal of Clinical Psychiatry

Neurology

Psychiatric Research Communications

American Psychiatric Association - ratings manual

COURSE WORK: Nonequilibrium Thermodynamics

Physical Biochemistry

Physical Chemistry

Pharmacokinetics

Protein Synthesis and Initiation

Lipid Metabolism and Membrane Biochemistry

Medical School curriculum of basic science and pathology

Medical School curriculum of clinical science

LABORATORY SKILLS: Column Chromatography

Isoelectric Focusing

HPLC

Carbon and Proton NMR

Centrifugation Techniques

Protein Purification

DNA, RNA, and Protein Electrophoresis

Organic Synthesis

Enzymatic Synthesis of Substrates

Antibody Production

Superfusion Techniques

Enzymatic Assays and Kinetics

BOARD CERTIFICATION: American Board of Psychiatry & Neurology

BIBLIOGRAPHY

ABSTRACTS:

1. Markovitz, PJ, Hanson, RW, Utter, MF: Induction of guinea pig cytosolic and mitochondrial phosphoenolpyruvate cCarboxykinase synthesis by cyclic-AMP, Federation Proceedings, February 1982.

2. Markovitz, PJ, Stagno, SJ, Calabrese, JR: Buspirone augmentation of fluoxetine in obsessive-compulsive disorder: An open add-on trial. Presented at Society of Biological Psychiatry Annual Meeting, May 1989.

3. Markovitz, PJ, Calabrese, JR, Schulz, SC: Fluoxetine in borderline personality disorder. Abstract presented at Society of Biological Psychiatry Annual Meeting, May 1990.

4. Markovitz, PJ, Calabrese, JR, Meltzer, HY, Schulz, SC: Fluoxetine in borderline personality disorder. Presented at National Clinical Drug Evaluation Unit Meetings (NCDEU), Key Biscayne, Florida, May 1990.

5. Calabrese JR, Delucchi, GA, Markovitz, PJ: Alternative agents in the treatment of manic depression: Focus on cycle frequency, duration, and amplitude. Abstract presented at Society of Biological Psychiatry Annual Meeting, May, 1990.

6. Markovitz, PJ, Calabrese JR, Schulz, SC, Trivedi C, Wagner S, Meltzer, HY: Comorbidity and treatment of borderline personality disorder. Abstract presented at International Convention on Treatment Refractory Depression, Amsterdam, Netherlands, June 25, 1992.

7. Markovitz, PJ, Comorbidity of migraines, PMS, IBS, fibromyalgia, neurodermatitis, and sleep apnea in borderline personality disorder: a possible serotonin link. Presented at the World Health Organization meeting on Personality Disorders, Cambridge, MA, September 1993.

8. Markovitz, PJ: Longitudinal efficacy of pharmacotherapy in borderline personality disorder: efficacy of sertraline and fluoxetine. Presented at the World Health Organization meeting on Personality Disorders, Cambridge, MA, September 1993.

9. Markovitz, PJ, Wagner, S: An open trial of venlafaxine in borderline personality disorder. Presented at National Clinical Drug Evaluation Unit Meetings (NCDEU), Orlando, Florida, May 1995.

10. Markovitz, PJ, Wagner, S, Stern HD: An open trial of venlafaxine in borderline personality disorder. Presented at the International Society for the Study of Personality Disorders, Dublin, Ireland, June, 1995.

11. Markovitz, PJ, Wagner, S, Stern HD: Selective serotonin reuptake inhibitors in borderline personality disorder: Correlation of Outcome with Sertraline, but not Fluoxetine or Paroxetine Serum Levels. . Presented at the International Society for the Study of Personality Disorders, Dublin, Ireland, June, 1995.

12. Markovitz, PJ, Wagner S: An open trial of venlafaxine in 68 patients with borderline personality disorder. Presented at the American Psychiatric Association Annual meeting. May, 1996.

13. Markovitz, PJ, Wagner S: An open trial of once versus twice daily nefazodone. Presented at American Psychiatric Association Annual Meeting, May 20, 1997. Abstract NR222.

14. Preskorn SH, Markovitz, PJ, Stahl SM, Ryan M, Borian FE, Hamid, S, Ieni JR, Jody DN: Once daily dosing of nefazodone for the treatment of depression in patients previously stabilized on

twice daily dosing. Presented at American Psychiatric Association Annual Meeting, May 20, 1997. Abstract NR224.

15. Markovitz PJ, Wagner SW. Venlafaxine in the treatment of somatic disorders in depressed and non-depressed patients. Presented at the American Psychiatric Association Annual Meeting, May 22, 1998.

ARTICLES:

1. Duffy, TH, Markovitz, PJ, Chuang, DT, Utter, MF, Nowak, T: Comparative Inhibition of Mitochondrial and Cytosolic Phosphoenolpyruvate Carboxykinase by Stereospecific Substrate Analogs. Proc. Natl. Acad. Sci., 78:11:6680-6683, 1981.

2. Shew, KF, Ho, HT, Nolan, LD, Markovitz, PJ, Richard, JP, Utter, MF, Frey, PA: Stereochemical Course of Thiophosphoryl Group Transfer Catalyzed by Mitochondrial Phosphoenolpyruvate Carboxykinase. Biochemistry, 23:8:1779-1783, 1984.

3. Markovitz, PJ, Chuang, DT, Cox, RP: A Multifunctional Peptide Catalyzing the First Two Steps of Lysine Degradation. Am. Jr. Human Genetics, September, 1984.

4. Markovitz, PJ, Chuang, DT, Cox, RP: Familial Hyperlysinemias: Purification and Characterization of the Bifunctional Aminoadipic Semialdehyde Synthase with Lysine- Ketoglutarate Reductase and Saccharopine Dehydrogenase Activities. Jr. Biol. Chem., 259:19:11643-11646, October 10, 1984.

5. Cox RP, Markovitz, PJ, Chuang, DT: Familial Hyperlysinemias - Multiple Enzyme Deficiencies Associated with the Bifunctional Aminoadipic Semialdehyde Synthase. Trans. Am. Clin. Climatol. Assoc., 97:69-81, 1985.

6. Chuang DT, Hu, CWC, Ku, LS, Markovitz, PJ, Cox, RP: Subunit Structure of Dihydro- lipoyl Transacylase Complex of Branched Chain Ketoacid Dehydrogenase Complex from Bovine Liver: Characterization of the Inner Transacylase Core. Jr. Biol. Chem., 260:25:13779-13786, November 5, 1985.

7. Markovitz, PJ, Cox, RP, Chuang, DT: Proteolytic Separation of Lysine-Ketoglutarate Reductase and Saccharopine Dehydrogenase from the Bifunctional Aminoadipic Semialdehyde Synthase. Jr. Biol. Chem., 262:19:9353-9358, July 5, 1987.

8. Markovitz, PJ, Stagno, SJ, Calabrese, JR: Buspirone Augmentation of Fluoxetine in Obsessive Compulsive Disorder. Am. J. Psychiatry, 147:5:798-800, 1990.

9. Calabrese, JR, Markovitz, PJ: Treatment of Depression: New Pharmacological Approaches. Primary Care, 18:2:421-434, 1991.

10. Markovitz, PJ, Calabrese, JR, Schulz, SC, Meltzer, HY: Fluoxetine in Borderline and Schizotypal Personality Disorder. Am. J. Psychiatry, 148:8:1064-1067, 1991.

11. Calabrese, JR, Markovitz, PJ, Kimmel, SE: Spectrum of Efficacy of Valproate in 78 Rapid - Cycling Manic Depressives. J. Clin. Psychopharmacology, 12:1:535-538, 1992.

12. Calabrese, JR, Meltzer, HY, Markovitz, PJ: Clozapine Prophylaxis in Rapid Cycling Bipolar Disorder. J. Clin. Psychopharmacology, 11:396-397, 1991.

13. Markovitz, PJ: Treatment of Anxiety in the Elderly. J. Clin. Psychiatry, 54 S:64-68, 1993.

14. Markovitz, PJ, Wagner, SC: Venlafaxine in the Treatment of Borderline Personality Disorder. Psychopharmacol Bull., 31:773-777, 1995.

LETTERS:

1. Markovitz, PJ, Calabrese, JR: Anticonvulsants in Manic Depression During Pregnancy. Psychosomatics, 31:118,1990.

2. Sunkhuredi, K, Markovitz, PJ: Trazodone Treatment of Trichotilomania. Am. J. Psychiatry,

150:523-524, 1990.

3. Schwartz, E, Markovitz, PJ: Fluoxetine Responsivity Mediated by Serum Levels, Not Dose. J. Clin.Psychopharmacology,13:363-364, 1993.

BOOK CHAPTERS:

1. Markovitz, PJ: Pharmacotherapy of Impulsivity, Aggression, and Related Disorders in Impulsivity and Aggression, eds. Hollander E and Stein D. John Wiley and Sons, pp 263-291, 1995.

IN PRESS/SUBMITTED:

1. Markovitz, PJ, Trivedi C, Wagner, SC, Schulz, SC, Meltzer, HY, Thompson, P: A Double-Blind, Placebo Controlled Trial of Fluoxetine in Borderline Personality Disorder. Submitted J. Clin. Psychiatry.

2. Markovitz, PJ, Wagner, SC: Serum Sertraline Levels Correlate with Positive Outcome in Borderline Personality Disorder. Submitted J Clin. Psychopharmacology.

3. Markovitz, PJ, Wagner, SC: Nefazodone in the Treatment of Borderline Personality Disorder. Submitted J. Personality Disorders.

4. Markovitz, PJ, Wagner, SC: Efficacy of Serotonergic Antidepressants in the Treatment of Somatic Disorders: Review of the Literature. Manuscript in preparation.