bipolar disorder articles
manic depression
parental loss
HOME  |  BIPOLAR DISORDER BOOKSTORE  |  HOTLINE  |  FIND A THERAPIST
Bipolar Disorder
Today Menu
 
 
BP Bookstore
Dr.'s Archive
DSM IV Diagnosis
BP Research
Articles
BP Bulletin Board
Family BP Board
Personal Stories
Consumers Speak Out
BP Self Care
Clinicians
BP Resources
BP FAQs
Free Medication
About
Contact
Links/Webrings

MH Webring

Click Here to Join the MH Today Webring

 Environment and vulnerability to major psychiatric illness: a case control study of early parental loss in major depression, bipolar disorder and schizophrenia.


Agid O, Shapira B, Zislin J, Ritsner M, Hanin B, Murad H, Troudart T, Bloch M, Heresco-Levy U, Lerer B.
Mol Psychiatry. 1999 Mar;4(2):106-8.
Dept of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

The current focus on identifying genes which predispose to psychiatric illness sharpens the need to identify environmental factors which interact with genetic predisposition and thus contribute to the multifactorial causation of these disorders. One such factor may be early parental loss (EPL). The putative relationship between early environmental stressors such as parental loss and psychopathology in adult life has intrigued psychiatrists for most of this century. We report a case control study in which rates of EPL, due to parental death or permanent separation before the age of 17 years were evaluated in patients with major depression (MD), bipolar disorder (BPD) and schizophrenia (SCZ), compared to individually matched, healthy control subjects (MD-Control, 79 pairs; BPD-Control, 79 pairs; SCZ-Control, 76 pairs). Loss of parent during childhood significantly increased the likelihood of developing MD during adult life (OR=3.8, P=0.001). The effect of loss due to permanent separation (P=0.008) was more striking than loss due to death, as was loss before the age of 9 years (OR=11.0, P=0.003) compared to later childhood and adolescence. The overall rate of EPL was also increased in BPD (OR=2.6, P=0.048) but there were no significant findings in any of the subcategories of loss. A significantly increased rate of EPL was observed in schizophrenia patients (OR=3.8, P=0.01), particularly before the age of 9 years (OR=4.3, P=0.01). Comparison of psychosocial, medical and clinical characteristics of subjects with and without a history of EPL, within the larger patient groups from which the matched samples were drawn (MD, n=136; BPD, n=107; SCZ, n=160), yielded few significant findings. Among the controls (n=170), however, subjects who had experienced EPL, reported lower incomes, had been divorced more frequently, were more likely to be living alone, were more likely to smoke or have smoked cigarettes and reported more physical illness (P=0.03-0.001). Long term neurobiological consequences of early environmental stressors such as maternal deprivation have been extensively studied in many animal species. Recently, enduring changes in hypothalamic-pituitary-adrenal axis function, including corticotrophin releasing factor gene expression, have received particular attention. Analogous processes may be implicated in the effect of EPL on human vulnerability to psychopathology, via alterations in responsiveness to stress. Genetic predisposition may influence the degree of susceptibility of the individual to the effects of early environmental stress and may also determine the psychopathological entity to which the individual is rendered vulnerable as a consequence of the stress.

PMID: 10208448 [PubMed - indexed for MEDLINE]

This article is provided for educational purposes only. No profit comes from this article. The more exposure I feel this abstract receives,, the less people with the BP will suffer. Clinicians need this training. Consumers and families desperately need to be educated. I am deeply grateful to the researchers that provide us with valuable information in assisting us with treatment and etiology.


Bipolar Disorder Today Newsletter

Join the BP Today Newsletter for information, resources and support. Or, send a blank email here.


MH Today Attention Deficit Bipolar Borderline Personality Depression
Gender Identity Narcissistic Personality PTSD Schizophrenia Suicide

Visit Mental Health Matters for information and articles. Get help to find a therapist or list your practice; and Psych Forums for message boards on a variety of MH topics.