Benzodiazepine Equivalence Chart
|
BENZODIAZEPINE
|
COMPARATIVE DOSE
|
TIME TO PEAK PLASMA LEVEL
|
HALF-LIFE
|
| Alprazolam |
.5
|
1 - 2
|
9 - 20
|
| Bromazepam |
3.0
|
.5 - 4
|
8 - 30
|
| Chlordiazepoxide |
25
|
1 - 4
|
24 - 100
|
| Clonazepam |
.25
|
1 - 4
|
10 - 60
|
| Clorazepate |
10
|
variable
|
1.3 - 120 * (unreliable absorption)
|
| Diazepam |
5
|
1 - 2
|
30 - 200 *
|
| Estazolam |
1
|
.5 - .6
|
8 - 24
|
| Flurazepam |
15
|
.5 - 1
|
40 - 250 *
|
| Halazepam |
40
|
1 - 3
|
30 - 96 *
|
| Ketazolam |
7.5
|
3.2
|
30 - 200
|
| Lorazepam |
1
|
2 - 4
|
8 - 24
|
| Nitrazepam |
2.5
|
.5 - 7
|
15 - 48
|
| Oxazepam |
15
|
2 - 3
|
3 - 25
|
| Prazepam |
10
|
2.5 - 6
|
30 - 100
|
| Quazepam |
7.5
|
1.5
|
39 - 120 *
|
| Temazepam |
10
|
2.5
|
3 - 25
|
| Triazolam |
.25
|
1 - 2
|
1.5 - 5
|
* metabolites
Clinical Handbook of
Psychotropic Drugs, 4th revised edition,
Bezchlibnyk-Butler et al. editors (Clarke Insitute of
Psychiatry, Toronto), Hogrefe & Huber.
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