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Benzodiazepine Equivalence Chart

 

BENZODIAZEPINE

COMPARATIVE DOSE

TIME TO PEAK PLASMA LEVEL

HALF-LIFE

Alprazolam

.5

1 - 2

9 - 20

Bromazepam

3.0

.5 - 4

8 - 30

Chlordiazepoxide

25

1 - 4

24 - 100

Clonazepam

.25

1 - 4

10 - 60

Clorazepate

10

variable

1.3 - 120 * (unreliable absorption)

Diazepam

5

1 - 2

30 - 200 *

Estazolam

1

.5 - .6

8 - 24

Flurazepam

15

.5 - 1

40 - 250 *

Halazepam

40

1 - 3

30 - 96 *

Ketazolam

7.5

3.2

30 - 200

Lorazepam

1

2 - 4

8 - 24

Nitrazepam

2.5

.5 - 7

15 - 48

Oxazepam

15

2 - 3

3 - 25

Prazepam

10

2.5 - 6

30 - 100

Quazepam

7.5

1.5

39 - 120 *

Temazepam

10

2.5

3 - 25

Triazolam

.25

1 - 2

1.5 - 5

* metabolites

Clinical Handbook of Psychotropic Drugs, 4th revised edition, Bezchlibnyk-Butler et al. editors (Clarke Insitute of Psychiatry, Toronto), Hogrefe & Huber.



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